Tag Archives: Protein Chips

History of Proteomics and Protein Chips

Nucleic Acid Microarrays The use of microarrays for gene expression profiling was first published in 1995. This technology allowed scientists to analyze thousands of mRNAs in a single experiment to determine whether expression is different in disease states. Unfortunately, mRNA levels within a cell are often poorly correlated with actual protein abundance. This can be due to many factors…

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Protein Chips

A DNA microarray as seen through a microscope. Protein chips look identical, except each spot corresponds to one of the organism’s thousands of proteins, instead of one of it’s genes. The intensity of the dot indicates the amount of protein present. Protein chips, also referred to as protein arrays or protein microarrays, are modeled after…

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